期刊論文
Publications
2024
The emergence of transposon-driven multidrug resistance in invasive nontypeable Haemophilus influenzae over the last decade
International Journal of Antimicrobial Agents
2024-09-19 | Journal article
DOI: 10.1016/j.ijantimicag.2024.107319
CONTRIBUTORS: Tsai-Wen Wan; Yu-Tsung Huang; Jian-Hong Lai; Qiao-Ting Chao; Hui-Hui Yeo; Tai-Fen Lee; Yung-Chi Chang; Hao-Chieh Chiu
Discovery of N,N'-diarylurea molecules with activity against multidrug-resistant Staphylococcus aureus
Archiv der Pharmazie
2024-04-30 | Journal article
CONTRIBUTORS: Hui-Hui Yeo; Yu-Hsuan Jao; Fan-Wei Yang; Min-Hsuan Kuo; Meng-Hsuan Lee; Chung-Wei Shiau; Hao-Chieh Chiu; Jung-Chen Su
Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria
RSC Medicinal Chemistry
2024 | Journal article
CONTRIBUTORS: Ling-Han Chen; Man-Yi Lin; Hsueh-Chun Lin; Fan-Wei Yang; Hsiao-Wei Liao; Chung-Wai Shiau; Hao-Chieh Chiu; Jung-Chen Su
2023
Performance assessment of the Bruker Biotyper MALDI-TOF MS for the identification of difficult-to-identify viridans group streptococci
Journal of Clinical Microbiology
2023-12 | Journal article
CONTRIBUTORS: Tsai-Wen Wan; Tai-Fen Lee; Xiang-Jun Chen; Yun-Tsung Hunag; Lee-Jene Teng; Po-Ren Hsueh; Hao-Chieh Chiu; Sandra S. Richter
Molecular epidemiology of bacteraemic vancomycin-resistant Enterococcus faecium isolates and in vitro activities of SC5005 and other comparators against these isolates collected from a medical centre in northern Taiwan, 2019-2020
Journal of Antimicrobial Chemotherapy
2023-02-01 | Journal article
CONTRIBUTORS: Tsai-Wen Wan; Hui-Hui Yeo; Tai-Fen Lee; Yu-Tsung Huang; Po-Ren Hsueh; Hao-Chieh Chiu
Repurposing the tyrosine kinase inhibitor nilotinib for use against intracellular multidrug-resistant Salmonella Typhimurium
Journal of Microbiology, Immunology and Infection
2023-01 | Journal article
DOI: 10.1016/j.jmii.2023.01.005
CONTRIBUTORS: Shih-Hsiu Chou; Tsai-Wen Wan; Chung-Wai Shiau; Ling-Han Chen; Hsueh-Chun Lin; Hao-Chieh Chiu
2022
Rapid Bactericidal Activity of SC5005 Combined with Docosahexaenoic Acid against Multidrug-Resistant Staphylococcus aureus Persisters and Biofilms
Antimicrobial Agents and Chemotherapy
2022-12-20 | Journal article
CONTRIBUTORS: Hui-Hui Yeo; Chung-Wei Shiau; Yu-Hsuan Jao; Tsai-Wen Wan; Hao-Chieh Chiu
Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteria
RSC Medicinal Chemistry
2022 | Journal article
CONTRIBUTORS: Hsueh-Chun Lin; Yi-Lun Wu; Cheng-Yun Hsu; Man-Yi Lin; Ling-Han Chen; Chung-Wai Shiau; Hao-Chieh Chiu
2021
A Novel Dibenzoxazepine Attenuates Intracellular Salmonella Typhimurium Oxidative Stress Resistance
Microbiology Spectrum
2021 | Journal article
DOI: 10.1128/Spectrum.01519-21
CONTRIBUTORS: Cheng-Yun Hsu, Yi-Lun Wu, Hsueh-Chun Lin, Man-Yi Lin, Shih-Hsiu Chou, Chung-Wai Shiau; Hao-Chieh Chiu
Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome
Virulence
2021 | Journal article
DOI: 10.1080/21505594.2021.1982501
CONTRIBUTORS: Zhao-Yi Wu, Anaamika Campeau, Chao-Hsien Liu, David J. Gonzalez, Masaya Yamaguchi, Shigetada Kawabata, Chieh-Hsien Lu, Chian-Yu Lai, Hao-Chieh Chiu & Yung-Chi Chang
SC5005 dissipates the membrane potential to kill Staphylococcus aureus persisters without detectable resistance
The Journal of antimicrobial chemotherapy
2021-04 | Journal article
CONTRIBUTORS: Chieh-Hsien Lu, Chung-Wai Shiau, Yung-Chi Chang, Hsiu-Ni Kung, Jui-Ching Wu, Chui-Hian Lim, Hui-Hui Yeo, Han-Chu Chang, Han-Sheng Chien, Sheng-Hsuan Huang, Wei-Kang Hung, Jun-Rong Wei, Hao-Chieh Chiu
Potentially conjugative plasmids harboring Tn6636, a multidrug-resistant and composite mobile element, in Staphylococcus aureus
Journal of microbiology, immunology, and infection
2021-03 | Journal article
DOI: 10.1016/j.jmii.2021.03.003
CONTRIBUTORS: Tsai-Wen Wan, Yu-Jung Liu, Yu-Ting Wang, Yu-Tzu Lin, Jia-Chuan Hsu, Jui-Chang Tsai, Hao-Chieh Chiu, Po-Ren Hsueh, Wei-Chun Hung, Lee-Jene Teng
2020
A celecoxib derivative eradicates antibiotic-resistant Staphylococcus aureus and biofilms by targeting yidc2 translocase
International Journal of Molecular Sciences
2020-12-07 | Journal article
CONTRIBUTORS: Shiou-Ru Tzeng, Yi-Wei Huang, Yao-Qing Zhang, Ching-Yi Yang, Han-Sheng Chien, Yi-Ru Chen, Sung-Liang Yu, Ching S. Chen and Hao-Chieh Chiu
2019
Loxapine, an antipsychotic drug, suppresses intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages
Journal of Microbiology, Immunology and Infection
2019 | Journal article
DOI: 10.1016/j.jmii.2019.05.006
CONTRIBUTORS: Ching-Yi Yang, Cheng-Yun Hsu, Chun-Sheng Fang, Chung-Wai Shiau, Ching S. Chen, Hao-Chieh Chiu
2018
A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli
Cell Death and Disease
2018 | Journal article
DOI: 10.1038/s41419-018-0423-2
CONTRIBUTORS: Cheng-Ju Kuo, Sin-Tian Wang, Chia-Mei Lin, Hao-Chieh Chiu, Cheng-Rung Huang, Der-Yen Lee, Geen-Dong Chang, Ting-Chen Chou, Jenn-Wei Chen &Chang-Shi Chen
Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant Staphylococcus aureus
Molecules
2018 | Journal article
DOI: 10.3390/molecules23010027
CONTRIBUTORS: Jung-Chen Su, Yu-Ting Huang, Chang-Shi Chen, Hao-Chieh Chiu and Chung-Wai Shiau
2017
Effects of toluidine blue O (TBO)-photodynamic inactivation on community-associated methicillin-resistant Staphylococcus aureus isolates
Journal of Microbiology, Immunology and Infection
2017 | Journal article
DOI: 10.1016/j.jmii.2014.12.007
CONTRIBUTORS: Sung-Pin Tseng, Wei-Chun Hung, Hsiao-Jan Chen, Yu-Tzu Lin, Hung-Sih Jiang, Hao-Chieh Chiu, Po-Ren Hsueh, Lee-Jene Teng, Jui-Chang Tsai
Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MS
Scientific Reports
2017 | Journal article
CONTRIBUTORS: Kang-Yi Su, Bo-Shiun Yan, Hao-Chieh Chiu, Chong-Jen Yu, So-Yi Chang, Ruwen Jou, Jia-Long Liu, Po-Ren Hsueh &Sung-Liang Yu
2016
Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis
Scientific Reports
2016 | Journal article
CONTRIBUTORS: Jung-Chen Su, Ai-Chung Mar, Szu-Hsien Wu, Wei-Tien Tai, Pei-Yi Chu, Chia-Yun Wu, Ling-Ming Tseng, Te-Chang Lee, Kuen-Feng Chen, Chun-Yu Liu, Hao-Chieh Chiu &Chung-Wai Shiau
In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA
Journal of Antimicrobial Chemotherapy
2016 | Journal article
CONTRIBUTORS: Han-Chu Chang, Yu-Ting Huang, Chang-Shi Chen, Yi-Wei Chen, Yu-Tsung Huang, Jung-Chen Su, Lee-Jeng Teng, Chung-Wai Shiau, Hao-Chieh Chiu
Mutation of the enterohemorrhagic Escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivo
Frontiers in Cellular and Infection Microbiology
2016 | Journal article
CONTRIBUTORS: Cheng-Ju Kuo, Jenn-Wei Chen, Hao-Chieh Chiu, Ching-Hao Teng, Tai-I Hsu, Pei-Jung Lu, Wan-Jr Syu, Sin-Tian Wang, Ting-Chen Chou and Chang-Shi Chen
2015
A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohnii
Journal of Antimicrobial Chemotherapy
2015 | Journal article
CONTRIBUTORS: Hsiao-Jan Chen, Wei-Chun Hung, Yu-Tzu Lin, Jui-Chang Tsai, Hao-Chieh Chiu, Po-Ren Hsueh, Lee-Jene Teng
2014
Sensitization of intracellular Salmonella enterica serovar Typhimurium to aminoglycosides in vitro and in vivo by a host-targeted antimicrobial agent
Antimicrobial agents and chemotherapy
2014-09-29 | Journal article
CONTRIBUTORS: Jung-Hsin Lo, Samuel K. Kulp, Ching-Shih Chen, Hao-Chieh Chiu
2013
Enterohaemorrhagic Escherichia coli O157: H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegans
Cellular Microbiology
2013 | Journal article
CONTRIBUTORS: T-C. Chou, H-C. Chiu, C-J. Kuo, C-M. Wu, W-J. Syu, W-T. Chiu, C-S. Chen
Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism
Biochemical and Biophysical Research Communications
2013 | Journal article
DOI: 10.1016/j.bbrc.2013.04.049
CONTRIBUTORS: Ya-Luen Yang, Po-Hsien Huang, Hao-Chieh Chiu, Samuel K. Kulp, Ching-Shih Chen, Cheng-Ju Kuo, Huan-Da Chen, Chang-Shi Chen
Vitamin e facilitates the inactivation of the kinase akt by the phosphatase PHLPP1
Science Signaling
2013 | Journal article
DOI: 10.1126/scisignal.2003816
CONTRIBUTORS: PO-HSIEN HUANG, HSIAO-CHING CHUANG, CHIH-CHIEN CHOU, HUILING WANG, SU-LIN LEE, HSIAO-CHING YANG, HAO-CHIEH CHIU, NAVAL KAPURIYA, DASHENG WANG, SAMUEL K. KULP, AND CHING-SHIH CHEN
2012
Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus
Bioorganic and Medicinal Chemistry
2012 | Journal article
DOI: 10.1016/j.bmc.2012.06.018
CONTRIBUTORS: Hao-Chieh Chiu, Su-Lin Lee, Naval Kapuriya, Dasheng Wang, Yi-Ru Chen, Sung-Liang Yu, Samuel K. Kulp, Lee-Jene Teng, Ching-Shih Chen
Escherichia coli O104:H4
Formosa Journal of Medicine 台灣醫學
2012 | Journal article
DOI: 10.6320/FJM.2012.16(2).09
CONTRIBUTORS: 陳小然(Hsiao-Jan Chen); 邱浩傑(Hao-Chieh Chiu); 鄧麗珍(Lee-Jene Teng)
Tularemia, A Potential Bioterrorism Threat 潛在的生物武器威脅：兔熱病
Formosa Journal of Medicine 台灣醫學
2012 | Journal article
DOI: 10.6320/FJM.2012.16(2).09
CONTRIBUTORS: 邱浩傑(Hao-Chieh Chiu) ； 顏伯勳(Bo-Shiun Yan)
2009
Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent
Journal of biomedical science
2009 | Journal article
CONTRIBUTORS: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger &Ching-Shih Chen
Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent
Antimicrobial Agents and Chemotherapy
2009 | Journal article
CONTRIBUTORS: Hao-Chieh Chiu, Samuel K Kulp, Shilpa Soni, Dasheng Wang, John S Gunn, Larry S Schlesinger, Ching-Shih Chen
Pharmacological exploitation of an off-target antibacterial effect of the cyclooxygenase-2 inhibitor celecoxib against Francisella tularensis
Antimicrobial Agents and Chemotherapy
2009 | Journal article
CONTRIBUTORS: Hao-Chieh Chiu, Jian Yang, Shilpa Soni, Samuel K Kulp, John S Gunn, Larry S Schlesinger, Ching-Shih Chen
2006
Comparison of Tir from enterohemorrahgic and enteropathogenic Escherichia coli strains: two homologues with distinct intracellular properties
Journal of Biomedical Science
2006 | Journal article
DOI: 10.1007/s11373-005-9034-x
CONTRIBUTORS: Chen-Hua Chuang, Hao-Jie Chiu, Sheng-Chieh Hsu, Jin-Yuan Ho, Wan-Jr Syu
Development of small-molecule cyclin D1-ablative agents
Journal of Medicinal Chemistry
2006 | Journal article
CONTRIBUTORS: Jui-Wen Huang, Chung-Wai Shiau, Jian Yang, Da-Sheng Wang, Hao-Chieh Chiu, Ching-Yu Chen, Ching-Shih Chen
2005
Functional analysis of EspB from enterohaemorrhagic Escherichia coli
Microbiology
2005 | Journal article
CONTRIBUTORS: Hao-Jie Chiu, Wan-Jr Syu
2003
Type III secretion of EspB in enterohemorrhagic Escherichia coli O157:H7
Archives of Microbiology
2003 | Journal article
DOI: 10.1007/s00203-003-0579-7
CONTRIBUTORS: Hao-Jie Chiu, Wen-Shiun Lin, Wan-Jr Syu